Manchester United vs Southampton: Premier League preview, team news, stats & head-to-head
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Manchester United full-back Diogo Dalot serves a one-game ban after he was sent off in the FA Cup win at Arsenal on Sunday.
Jonny Evans, Mason Mount, Luke Shaw and Victor Lindelof are likely to remain out.
Southampton midfielder Flynn Downes is back in training and could feature following three games out with a thigh injury.
Will Smallbone is in contention to make his first Premier League appearance since 19 October after returning from injury in the FA Cup win against Swansea City.
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